Shiranee Sriskandan

Diversity of penicillin-binding protein 2x in Streptococcus pyogenes from England and Wales, 2001 to 2015

The paper analyzes PBP2x sequence diversity in S. pyogenes isolates from England and Wales, finding mutations associated with reduced beta-lactam susceptibility and macrolide resistance.

M1 protein expression determines niche-specific spread of Streptococcus pyogenes

This study shows that secreted M protein, not cell-surface M protein, is critical for lymphatic survival and systemic infection of Streptococcus pyogenes in mice.

Gene flow between environmental and enteric bacteria with environmental coselection for metal and antibiotic resistance genes: A case study

This study identifies gene flow and co-selection for antibiotic and metal resistance genes in industrial sediments and water, highlighting heavy metals as a selective pressure for multidrug resistance.

Lymphatic dissemination is a major route of systemic invasion by diverse extracellular bacteria in soft tissue infection

This study shows that lymphatic dissemination through sequential lymph nodes is a major route for systemic spread of extracellular bacteria in soft tissue infections.

Elevated risk of invasive group A streptococcal disease and host genetic variation in the human leukocyte antigen locus

The paper identifies an association between the HLA-DQA1*01:03 allele and increased risk of invasive group A streptococcal disease using case-control studies and HLA imputation.