Author

Cristian Roca

University of North Carolina at Chapel HillORCID 0000-0003-2522-0360Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Microbiology· 2

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Research Focus:host-pathogen & immune response· 2 Organism:bacteria (other)· 1 Organism:human· 1

Frequent Co-Authors

Matthew A. GreenwaldiD· 2 shared Matthew C. WolfgangiD· 2 shared Matthew G. HiggsiD· 2 shared Ashelyn E. SiddersiD· 1 shared Brian P. ConloniD· 1 shared David B. HilliD· 1 shared Jade K. Macdonald· 1 shared Jerome CarpenteriD· 1 shared

Activity by Year

2024-2025 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 33 mutual co-author links

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2 shared papersMicrobiology

Matthew A. GreenwaldORCID

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2 papers

Recent·Most cited

MicrobiologymBioPeer-reviewedMay 15, 2025

Flagellar motility and the mucus environment influence aggregation mediated antibiotic tolerance of Pseudomonas aeruginosa in chronic lung infection

Matthew G. Higgs, Matthew A. Greenwald, Cristian Roca…·Matthew C. Wolfgang

This study shows that loss of flagellar motility in Pseudomonas aeruginosa increases aggregation and antibiotic tolerance in the mucus environment of chronic lung infections.

9 citations

bacteria (other)experimental assay

𝕏 PostBluesky

MicrobiologymBioPeer-reviewedApr 23, 2024

Mucus polymer concentration and in vivo adaptation converge to define the antibiotic response of Pseudomonas aeruginosa during chronic lung infection

Matthew A. Greenwald, Suzanne L. Meinig, Lucas M. Plott…·Matthew C. Wolfgang

This study shows that increased mucin and eDNA concentrations in mucus enhance Pseudomonas aeruginosa antibiotic tolerance, and establishes an in vitro model to replicate this tolerance observed in sputum.

9 citations

humanexperimental assay

𝕏 PostBluesky