Brian P. Conlon

A host-directed adjuvant resuscitates and sensitizes intracellular bacterial persisters to antibiotics

This study identifies a host-directed adjuvant, KL1, that increases intracellular bacterial energy and sensitizes persisters to antibiotics by modulating host immune responses and reducing reactive species production.

Flagellar motility and the mucus environment influence aggregation mediated antibiotic tolerance of Pseudomonas aeruginosa in chronic lung infection

This study shows that loss of flagellar motility in Pseudomonas aeruginosa increases aggregation and antibiotic tolerance in the mucus environment of chronic lung infections.

The innate immune protein calprotectin incapacitates the bactericidal activity of β-lactam antibiotics

This study shows that calprotectin reduces β-lactam antibiotic efficacy by inactivating bacterial autolysins through zinc sequestration, independent of bacterial growth.

The impact of transplant location on the gut microbiome and resistome in patients undergoing hematopoietic stem cell transplantation at home versus in the hospital

This study compares the gut microbiome and resistome of patients undergoing home versus hospital hematopoietic stem cell transplantation, finding no significant differences but noting confounding factors in secondary analyses.