Rafael Franco

This paper introduces a dual inhibitor targeting G9a and GSK-3β for Alzheimer's disease, showing improved memory and synaptic function in a mouse model.

The paper shows a bivalent ligand enhances CB2R homodimerization, leading to increased Gi binding potency and β-arrestin recruitment.

The paper introduces a fluorescent ligand for visualizing D1 and D5 dopamine receptors, showing high affinity and selectivity with applications in fluorescence microscopy.

This paper describes the synthesis and characterization of fluorescent ligands for imaging and ligand screening of dopamine D2-like receptors, showing high affinity and selectivity.

DIMERBOW provides a database and web tool to explore potential GPCR dimer interfaces from solved structures to aid in modeling homomers.