Gemma Navarro

Dual Inhibitors Targeting G9a and GSK-3B: Translational Perspectives on Alzheimer's Disease Treatment

This paper introduces a dual inhibitor targeting G9a and GSK-3β for Alzheimer's disease, showing improved memory and synaptic function in a mouse model.

The interplay between CB2 and NMDA receptors in Parkinsons disease

This study investigates the interaction between CB2 and NMDA receptors in Parkinson's disease, showing that CB2R activation counteracts neuroinflammation and NMDAR signaling induced by alpha-synuclein fibrils.

Homodimerization of CB2 cannabinoid receptor triggered by a bivalent ligand enhances cellular signaling

The paper shows a bivalent ligand enhances CB2R homodimerization, leading to increased Gi binding potency and β-arrestin recruitment.

Shedding Light on the D1-Like Receptors: A Fluorescence-Based Toolbox for Visualization of the D1 and D5 Receptors

The paper introduces a fluorescent ligand for visualizing D1 and D5 dopamine receptors, showing high affinity and selectivity with applications in fluorescence microscopy.

Fluorescent Tools for Imaging and Ligand Screening of Dopamine D2-Like Receptors

This paper describes the synthesis and characterization of fluorescent ligands for imaging and ligand screening of dopamine D2-like receptors, showing high affinity and selectivity.

Preventing Jacob-induced transcriptional inactivation of CREB protects synapses from β-amyloid in Alzheimer's Disease

The paper shows that Nitarsone prevents Aβ-induced CREB inactivation and synaptic loss in AD models by blocking Jacob-mediated signalosome assembly.

Nr2e3 functional domain ablation by CRISPR-Cas9D10A identifies a new isoform and generates Retinitis Pigmentosa and Enhanced S-cone Syndrome models

This paper generates two Nr2e3 mouse models using CRISPR-Cas9-D10A nickase to study retinal dystrophies, identifying a new short isoform and phenotypes resembling human RP and ESCS.

DIMERBOW: exploring possible GPCR dimer interfaces

DIMERBOW provides a database and web tool to explore potential GPCR dimer interfaces from solved structures to aid in modeling homomers.