Hannes Schihada

Subcellular pharmacology of a novel cell-permeable fluorescent phosphodiesterase inhibitor using advanced fluorescence microscopy

The paper develops a fluorescent PDE4 inhibitor to visualize drug-target interactions in living cells using advanced fluorescence microscopy techniques.

Functional diversity of GPCR-Gustducin complexes controls signaling output and suppresses alternative pathways

The paper develops biosensors to study GPCR-Gustducin interactions and finds that some non-taste GPCRs suppress signaling by forming unproductive complexes that block alternative pathways.

Shedding Light on the D1-Like Receptors: A Fluorescence-Based Toolbox for Visualization of the D1 and D5 Receptors

The paper introduces a fluorescent ligand for visualizing D1 and D5 dopamine receptors, showing high affinity and selectivity with applications in fluorescence microscopy.

Fluorescent Tools for Imaging and Ligand Screening of Dopamine D2-Like Receptors

This paper describes the synthesis and characterization of fluorescent ligands for imaging and ligand screening of dopamine D2-like receptors, showing high affinity and selectivity.

Cryo-EM structure of cell-free synthesized human histamine H2 receptor coupled to heterotrimeric Gs protein in lipid nanodisc environment

The paper presents the cryo-EM structure of the human histamine H2 receptor complexed with Gs protein in lipid nanodiscs, revealing insights into ligand binding and G protein coupling mechanisms.