Author

Emanuel H. W. Bruckisch

University of CologneORCID 0000-0003-2551-5919Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Assay:proteomics· 2 Organism:C. elegans· 1 Research Focus:cell type annotation· 1 Organism:human· 1 Research Focus:protein structure prediction· 1

Frequent Co-Authors

Filip LiebschiD· 2 shared Günter SchwarziD· 2 shared Ann-Kathrin Huber· 1 shared Anne LanjuiniD· 1 shared Caroline HeintziD· 1 shared Elmar BehrmanniD· 1 shared Fynn R. EggersmanniD· 1 shared Jan RiemeriD· 1 shared

Activity by Year

2021-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 20 mutual co-author links

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2 shared papersNeuroscience

Filip LiebschORCID

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3 papers

Recent·Most cited

NeuroscienceNature CommunicationsPeer-reviewedSep 3, 2026

Redox-dependent synaptic clustering of gephyrin

Maria-Theresa Gehling, Emanuel H. W. Bruckisch, Fynn R. Eggersmann…·Günter Schwarz

This study shows that ROS-induced oxidation of gephyrin cysteines promotes synaptic multimerization and enhances inhibitory receptor clustering through disulfide bridges.

1 citation

experimental assay

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NeuroscienceEMBO Molecular MedicinePeer-reviewedJun 30, 2026

Impaired gephyrin G-domain trimerization and phase separation in a patient with developmental epileptic encephalopathy

Emanuel H. W. Bruckisch, Marcelo de Melo Aragão, Thais dos Santos Rohde…·Filip Liebsch

The paper identifies a de novo G134R mutation in gephyrin that impairs oligomerization, phase separation, and synaptic clustering, contributing to developmental epileptic encephalopathy.

DOI 10.1038/s44321-026-00474-w

humanproteomics

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GeneticsbioRxivPreprintDec 22, 2021

A Single-copy Knock In Translating Ribosome ImmunoPrecipitation (SKI TRIP) tool kit for tissue specific profiling of actively translated mRNAs in C. elegans.

Laura E. Wester, Anne Lanjuin, Emanuel H. W. Bruckisch…·William B. Mair

The paper introduces SKI TRIP, a method for profiling cell type-specific translation in C. elegans using single-copy knock-in of a FLAG-tagged ribosomal subunit.

DOI 10.1101/2021.12.22.473890

C. elegansproteomics

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