Miles Hamilton Linde

The paper identifies and isolates human AML leukemia stem cells using single-cell multi-omics and establishes a prognostic gene signature for clinical relevance.

This study shows that overexpressing c-Jun in CAR-T cells enhances their ability to maintain PD-1+Tcf1+ stem-like cells in tumors and improves response to PD-L1 blockade.

This study identifies new functionally and molecularly distinct multipotent progenitors in adult human hematopoiesis using multiomic single cell analyses and functional assays.