Author

Shivani Srivastava

Fred Hutch Cancer CenterORCID 0000-0002-1626-8402Unclaimed ORCID profile · follow to get notified of new preprints

Additional preprints under this name without ORCID

Shivani Srivastava1 paper · Rutgers New Jersey Medical School

Biology Disciplines

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Research Focus:cancer & tumor microenvironment· 2 Research Focus:cell type annotation· 2 Approach:experimental assay· 2 Organism:mouse· 2 Assay:bulk RNA-seq· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:drug response / drug discovery· 1 Approach:genetic perturbation / CRISPR· 1

Frequent Co-Authors

Andrew J. SnyderiD· 2 shared Ekram A. Gad· 2 shared Emma BinghamiD· 2 shared Megha Sarvothama· 2 shared Mitchell G. KluesneriD· 2 shared Sarah M. GarrisoniD· 2 shared Sydney A. MarshiD· 2 shared Victor ZepedaiD· 2 shared

Activity by Year

2025-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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2 shared papersImmunology

Andrew J. SnyderORCID

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2 papers

Recent·Most cited

ImmunologyScience ImmunologyPeer-reviewedMar 6, 2026

Modulating AP-1 enables CAR-T cells to establish an intratumoral PD-1+Tcf1+ stem-like reservoir and overcomes resistance to PD-1 axis blockade

Andrew J. Snyder, Sarah M. Garrison, Mitchell G. Kluesner…·Shivani Srivastava

This study shows that overexpressing c-Jun in CAR-T cells enhances their ability to maintain PD-1+Tcf1+ stem-like cells in tumors and improves response to PD-L1 blockade.

4 citationstop 1%

mousebulk RNA-seq

𝕏 PostBluesky

ImmunologybioRxivPreprintDec 15, 2025

NKTR-255, a polymer-conjugated IL-15, synergizes with CAR-T cell therapy to activate endogenous anti-tumor immunity and improve tumor control

W. Sam Nutt, Mitchell G. Kluesner, Emma Bingham…·Shivani Srivastava

This study shows that combining NKTR-255 with CAR-T therapy enhances tumor control by boosting CAR-T function and endogenous anti-tumor immunity in solid tumors.

1 citation

mouseexperimental assay

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