Sean McKinney

The paper identifies gene expression patterns in cnidocytes and spirocytes of Nematostella vectensis, revealing specialized transcriptional programs for cnidogenesis.

The paper identifies pre-hematopoietic stem cells and their niche using spatial transcriptomics in the AGM region, revealing spatial signaling patterns and cellular interactions that support HSC development.

This study uses X-ray tomography to compare internal polyp architecture across four coral species, revealing species-specific patterns of tissue organization and connectivity.

This study investigates how variations in centromeric alpha-satellite array size affect centromere function during mitosis, finding that smaller arrays are more prone to missegregation and cohesion fatigue.

This study investigates nucleolar changes during zebrafish oogenesis and finds similar patterns in mouse oocytes, suggesting conserved nucleolar remodeling for translational adaptation.

This study shows TDP-43 amyloid forms only when its C-terminal domain arrests in soluble clusters, and this process can be inhibited by co-expressing an oligomeric binder.

This study shows that loss of SPECC1L in cranial neural crest cells causes increased Hedgehog signaling and craniofacial defects similar to human syndrome.

The paper presents T2T reference genomes from a multi-generational pedigree to study genetic and epigenetic inheritance across the complete genome.

This study assembles human Robertsonian chromosomes, identifies a common breakpoint and centromere epigenetic changes, and explores structural features enabling their formation.

This paper identifies the apple snail Pomacea canaliculata as a new model for studying camera-type eye regeneration, showing its ability to regenerate complete eyes and the role of pax6 in eye development.

This study investigates reproductive adaptations in Astyanax mexicanus under nutrient limitation, finding cavefish maintain breeding ability under starvation due to increased maternal nutrient deposition and specific gene expression changes.

The paper presents haplotype-resolved genomes of six ape species with high accuracy and provides comparative analyses to study evolutionary diversity and gene family evolution.

The paper identifies enhancers regulating Chd7 expression in neural crest cells and validates their function in chick embryos, revealing tissue-specific regulation of a chromatin remodeller.

The paper investigates epigenetic regulation of rDNA arrays, showing DNA methylation controls their activity and inheritance across generations.

This study identifies a role for smed-pak1 and the Hippo/Yorkie pathway in integrating anterior-posterior and medio-lateral body axes during planarian regeneration.

The paper investigates how shared retinoic acid response elements regulate nascent transcription of Hoxb genes in mouse neural tube development using smFISH.

The paper shows that rRNA transcription by Pol I is essential for nucleolar structure and liquid-liquid phase separation in mouse embryos.

This paper characterizes a new planarian isolate, Girardia sp. (Guanajuato), at morphological, cellular, and molecular levels to identify unique traits and facilitate future comparisons.

The paper identifies dynamic stem cell microenvironments in planarians that support regeneration by associating with diverse cell types.

This study shows that Hedgehog signaling is essential for PGC specification and endomesodermal patterning in Nematostella, suggesting zygotic induction rather than maternal factors.

The paper generates a brain atlas of surface fish and three cavefish populations, revealing convergent neuroanatomical changes associated with evolved behavioral traits.

This paper introduces an electroporation method for efficient shRNA delivery in Nematostella vectensis to enable rapid gene knockdown.

The paper identifies two antimicrobial peptides that regulate long-term memory in Drosophila but not short-term memory or instinctive behavior.

The paper identifies a nuclear hormone receptor and lipid metabolism axis critical for reproductive organ maintenance and regeneration in planarians.

This paper develops a simple and adaptable chromosome preparation protocol for invertebrates, enabling karyotyping and downstream applications in species lacking cell lines.