Daniel Lagos

This study shows that high mitochondrial DNA heteroplasmy in human organoids with the m.3243A>G mutation causes cortical neuronal disturbances, including axonal degeneration and apoptosis, similar to MELAS patients.

This study shows that MFN2 mutations in CMT2A patients alter mitochondrial fission and metabolism through distinct DRP1 dysregulation mechanisms.

This study investigates how OPA1 and its disease-causing mutants affect mitochondrial nucleoid distribution using high-resolution microscopy and a novel model.

This study identifies mitochondrial dysfunction and mtDNA damage as early triggers of immune response in PM-Mito and IBM, linking mitochondrial abnormalities to inflammation and disease progression.