András Lakatos

The transcription factor BCL11A restores differentiation potential to aged oligodendrocyte progenitor cells

The paper identifies BCL11A as a transcription factor that restores differentiation potential in aged oligodendrocyte progenitor cells through computational analysis and experimental validation.

scRepresenter: a workflow for computing, integrating and benchmarking cellular representations in single-cell transcriptomics

scRepresenter provides a workflow to compute, integrate, and benchmark cellular representations from scRNA-seq data using different methods for complex disease analysis.

Organoids reveal niche-specific mechanotransduction-guided human cortical patterning and cell fate acquisition

This study uses organoids to show that disrupting the LINC complex affects human cortical cell fate and organization by altering mechanosensing and nuclear mechanics.

Myelin basic protein is an RNA chaperone in microglial nuclear retro-transport

The paper identifies myelin basic protein (MBP) as an RNA chaperone that facilitates microglial nuclear import of myelin RNA, with implications for multiple sclerosis pathology.

Mitochondrial DNA heteroplasmy drives cortical neuronal disturbances in human organoids harbouring the common m.3243A>G mutation

This study shows that high mitochondrial DNA heteroplasmy in human organoids with the m.3243A>G mutation causes cortical neuronal disturbances, including axonal degeneration and apoptosis, similar to MELAS patients.

A chemically defined and xeno-free hydrogel system for regenerative medicine.

The paper develops a chemically defined, xeno-free hydrogel system that supports hPSC differentiation into multiple tissue types and improves hepatocyte retention in vivo.

MEA-NAP compares microscale functional connectivity, topology, and network dynamics in organoid or monolayer neuronal cultures

MEA-NAP analyzes microscale functional connectivity and network dynamics from MEA recordings in neuronal cultures, revealing differences in topology and network development.

Cerebral organoids at the air-liquid interface generate diverse nerve tracts with functional output

This study shows that cerebral organoids cultured at the air-liquid interface form functional nerve tracts with diverse morphologies and connectivity.