The paper shows that opioidergic signals in the medial prefrontal cortex activate the descending pain inhibitory system to initiate placebo analgesia in neuropathic pain rats.

18 citationstop 1%

ratexperimental assay

𝕏 PostBluesky

NeuroscienceJournal of Neuroscience MethodsPeer-reviewedSep 9, 2022

Catecholaminergic cell type-specific expression of Cre recombinase in knock-in transgenic rats generated by the Combi-CRISPR technology

Natsuki Matsushita, Kayo Nishizawa, Shigeki Kato…·Kazuto Kobayashi

The paper characterizes TH-Cre knock-in rats generated via Combi-CRISPR, showing cell type-specific Cre expression and normal catecholamine metabolism and behavior.

3 citations

ratexperimental assay

𝕏 PostBluesky

NeurosciencebioRxivPreprintApr 11, 2022

Highly selective transgene expression through double-floxed inverted orientation system by using a unilateral spacer sequence

Natsuki Matsushita, Shigeki Kato, Kayo Nishizawa…·Kazuto Kobayashi

The paper introduces a DIO/USS system to enhance Cre-dependent transgene expression specificity by preventing Cre-independent recombination during vector production.

2 citations

experimental assay

𝕏 PostBluesky