Antonina Roll‐Mecak

This study shows TTC5 regulates tubulin autoregulation in neurons, affecting morphology and migration, and links TTC5 dysfunction to neurodevelopmental disorders.

The paper introduces a high-throughput 3D culture system for imaging axonal processes in human iPSC-derived neurons, enabling efficient study of microtubule dynamics and cargo transport.

The paper describes a modified multi-color TIRF microscope that enables simultaneous IRM and single molecule TIRF imaging of microtubules and EB1 proteins.

This study identifies substrate preferences and regulatory mechanisms of TTLL glycylases, showing how tubulin glutamylation and polyglycylation influence TTLL10 activity and microtubule modification.

The paper reports cryo-EM structures of human α1B/βI+βIVb microtubules in GDP and GTP-like states, revealing isoform-specific sequence variations affecting polymerization interfaces and microtubule dynamics.