Elizabeth L. Daley

The paper introduces a high-throughput 3D culture system for imaging axonal processes in human iPSC-derived neurons, enabling efficient study of microtubule dynamics and cargo transport.

The paper identifies that poly-GR binds ribosomal RNA and shows that modified rRNA oligonucleotides can mitigate poly-GR toxicity in models of C9orf72 ALS/FTD.

The paper identifies eRF1 and NMD as modifiers of C9orf72 repeat expansion toxicity by analyzing nucleocytoplasmic proteomic changes in ALS/FTD.

The paper models gene expression networks to predict interchromosomal organization during human embryonic stem cell differentiation and finds that coordinate gene regulation correlates with 3D chromosome organization.