Author

Jakub Žiak

Johns Hopkins UniversityORCID 0000-0001-9840-6006Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Approach:experimental assay· 6 Organism:mouse· 5 Research Focus:cell type annotation· 2 Assay:bulk RNA-seq· 1 Research Focus:development & morphogenesis· 1 Research Focus:differential expression· 1 Organism:human· 1 Assay:imaging· 1

Frequent Co-Authors

Alex L. KolodkiniD· 4 shared Sriram SudarsanamiD· 3 shared Joelle M. Dorskind· 2 shared Luis Guzman-ClaveliD· 2 shared Martin BalaštíkiD· 2 shared Randal Hand· 2 shared Romana WeissováiD· 2 shared Aleš Stuchlı́kiD· 1 shared

Activity by Year

2020-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 17 mutual co-author links

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4 shared papersNeuroscience

Alex L. KolodkinORCID

Mutual co-authors in cluster

Author profile →

6 papers

Recent·Most cited

Tubulin autoregulation mediator TTC5 regulates neuronal morphology and migration

Stephanie L. Sarbanes, Jakub Žiak, Alex L. Kolodkin, Antonina Roll‐Mecak

This study shows TTC5 regulates tubulin autoregulation in neurons, affecting morphology and migration, and links TTC5 dysfunction to neurodevelopmental disorders.

bioRxiv · Jun 24, 2026 · PreprintCell Biology

Mef2c Controls Postnatal Callosal Axon Targeting by Regulating Sensitivity to Ephrin Repulsion

Sriram Sudarsanam, Luis Guzman-Clavel, Nyle Dar, Jakub Žiak, Naseer Shahid, Xinyu O Jin, Alex L. Kolodkin

This paper shows that Mef2c regulates the development of cortical neurons and their postnatal axon targeting by modulating EphA6 expression and sensitivity to EphrinA5 repulsion.

Journal of Neuroscience · Apr 14, 2025Peer-reviewedNeuroscience

Prolyl isomerase FKBP12 reduces axon growth and negatively regulates microtubule polymerization by inhibiting CRMP2A

Romana Weissová, Jan Sabo, Djamel Eddine Chafai, Jakub Žiak, Peter Buran, Satish Bodakuntla, Carsten Janke, Zdeněk Lánský, Martin Balaštík

This paper shows FKBP12 inhibits CRMP2A-mediated microtubule polymerization and axon growth by binding to unphosphorylated CRMP2A.

bioRxiv · Jan 13, 2025 · PreprintNeuroscience

Drebrin Regulates Collateral Axon Branching in Cortical Layer II/III Somatosensory Neurons

Joelle M. Dorskind, Sriram Sudarsanam, Randal Hand, Jakub Žiak, Maame Amoah-Dankwah, Luis Guzman-Clavel, John Lee Soto-Vargas, Alex L. Kolodkin

This study identifies drebrin's role in regulating axon branching in cortical neurons and develops tools to analyze single-cell morphology.

Journal of Neuroscience · Oct 5, 2023Peer-reviewedNeuroscience

MAP1B Regulates Cortical Neuron Interstitial Axon Branching Through the Tubulin Tyrosination Cycle

Jakub Žiak, Joelle M. Dorskind, Brian Trigg, Sriram Sudarsanam, Randal Hand, Alex L. Kolodkin

This study identifies GSK3β's role in promoting interstitial axon branching in cortical neurons by modulating MAP1B and the tubulin tyrosination cycle.

bioRxiv · Oct 2, 2023 · PreprintNeuroscience

CRMP2 mediates Sema3F-dependent axon pruning and dendritic spine remodeling

Jakub Žiak, Romana Weissová, Kateřina Jeřábková, Martina Janikova, Roy Maimon, Tomáš Petrásek, Barbora Pukajova, Mengzhe Wang, Monika S. Brill, Marie Kleisnerova, Petr Kašpárek, Xunlei Zhou, Gonzalo Álvarez-Bolado, Radislav Sedláček, Thomas Misgeld, , Martin Balaštík

This study shows CRMP2 is essential for Sema3F-dependent axon pruning and dendritic spine remodeling, linking its dysfunction to ASD-like behaviors in mice.

EMBO Reports · Jan 9, 2020Peer-reviewedNeuroscience