Pharmacology & ToxicologybioRxivPreprint
Helix-8 and Carboxyl Terminal Tail Regulation of Proteinase Activated Receptor-4 (PAR4) signalling
Pierre E. Thibeault, Amr A. K. Mousa, Victor Michael Mirka, Rithwik Ramachandran
This study investigates how the 8th-helix and carboxyl terminal tail of PAR4 regulate signaling by affecting G protein activation, β-arrestin recruitment, and interactions with regulatory proteins.
DOI 10.1101/2025.02.10.637468