Author

Frauke Senger

Heidelberg University

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Molecular Biology· 2 Cell Biology· 1 Physiology· 1

Signature Assays, Organisms & Methods

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Assay:bulk RNA-seq· 3 Research Focus:differential expression· 3 Organism:mouse· 3 Approach:statistical model· 3 Approach:experimental assay· 2 Research Focus:cell type annotation· 1 Research Focus:cell-cell communication· 1 Research Focus:development & morphogenesis· 1

Frequent Co-Authors

Norbert FreyiD· 4 shared Abel Martín-Garrido· 2 shared Arica BeisawiD· 2 shared Ashraf Yusuf RangreziD· 2 shared Nesrin Schmiedel· 2 shared Tapan Kumar Baral· 2 shared Alina Bektimirova· 1 shared Anca Kliesow RemesiD· 1 shared

Activity by Year

2025-2026 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 29 mutual co-author links

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4 shared papersMolecular Biology

Norbert FreyORCID

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Author profile →

4 papers

Recent·Most cited

FYCO1 improves postischemic cardiac remodeling via enhanced autophagic flux and attenuation of proinflammatory signaling

Frauke Senger, Susanne S. Hille, Anca Kliesow Remes, Tapan Kumar Baral, Abel Martín-Garrido, Nesrin Schmiedel, Christian Kühn, Oliver J. Müller, Ashraf Yusuf Rangrez, Johannes Backs, Arica Beisaw, Jörg Heineke, Norbert Frey

This study identifies FYCO1 as a regulator of autophagy that improves cardiac remodeling after myocardial infarction by enhancing autophagic flux and reducing inflammation.

bioRxiv · Jul 8, 2026 · PreprintMolecular Biology

Cardiomyocyte autophagy promotes a pro-regenerative immune response during cardiac regeneration

Florian Constanty, Bailin Wu, Srishti Shekhar, Alina Bektimirova, Vasiliki Bakali, Lucia Blasco Almodovar, Frauke Senger, Norbert Frey, Arica Beisaw

This study shows that cardiomyocyte autophagy promotes a pro-regenerative immune response by modulating macrophage gene expression during zebrafish cardiac regeneration.

bioRxiv · Mar 18, 2026 · PreprintCell Biology

Loss of cardiomyocyte eukaryotic elongation factor 1A2 in mice triggers cardiomyopathy due to defective proteostasis

Abel Martín-Garrido, Nadine Weyrauch, Jorge Ruiz‐Orera, Jeanette Eresch, Sonja Reitter, Julio Cordero, Frauke Senger, Viktoria Scheich, Andrea Grund, Merve Keleş, Nina Weinzierl, Ellen Hofmann, Felix A. Trogisch, Shruthi Hemanna, Michael Buettner, , Joerg Heineke

This study shows that loss of eEF1A2 in cardiomyocytes causes cardiomyopathy through proteostasis defects, and mTORC1 inhibition can reverse the condition.

bioRxiv · Feb 18, 2026 · PreprintPhysiology

TRIM24 preserves cardiomyocyte immune quiescence by repressing interferon/STAT signaling

Marco Neu, Ankush Borlepawar, Anushka Deshpande, Laura Neuberger, Tapan Kumar Baral, Frauke Senger, Elke Hammer, Nesrin Schmiedel, Michael Hausmann, Norbert Frey, Manju Kumari, Ashraf Yusuf Rangrez

This study identifies TRIM24 as a chromatin regulator that suppresses inflammatory signaling in cardiomyocytes, preventing cardiac inflammation and heart failure progression.

bioRxiv · Nov 13, 2025 · PreprintMolecular Biology