Susanne S. Hille

FYCO1 improves postischemic cardiac remodeling via enhanced autophagic flux and attenuation of proinflammatory signaling

This study identifies FYCO1 as a regulator of autophagy that improves cardiac remodeling after myocardial infarction by enhancing autophagic flux and reducing inflammation.

Soluble epoxide hydrolase upregulation in Alzheimer's disease promotes blood-brain barrier dysfunction

This study shows that soluble epoxide hydrolase in astrocytes contributes to vascular instability in Alzheimer's disease, and its deletion reduces vascular amyloid burden and preserves vascular structure.

Endothelial expression of ZBTB16 protects against cardiac aging

This study identifies ZBTB16 as a critical regulator of endothelial function in aging, showing its protective role against cardiac dysfunction through suppression of pro-fibrotic signaling.

Titin cleavage impairs cardiac mechanical connectivity to drive diastolic failure and fibrosis

This study shows that titin cleavage in mice causes concentric cardiac remodeling, diastolic dysfunction, and fibrosis by disrupting mechanical connectivity.