Kathryn A. Patras

This study identifies immune signatures in mice and human urine that predict preterm birth risk following UTI, highlighting cytokines like IL-10 and IL-15 as potential therapeutic targets.

This study shows that type 2 diabetes increases susceptibility to vaginal group B Streptococcus colonization through impaired cytokine responses, not via glucose availability or microbiome changes.

This study shows that bacteriophages can reduce uropathogenic E. coli (UPEC) colonization in vitro and in a mouse model, suggesting phage therapy as a potential UTI prevention strategy.

This study uses human nasal epithelial organoids to investigate how different bacteria colonize nasal tissue and induce cytokine responses, finding differential effects on chemokines and inflammasome signaling.

This study develops human bladder organoids to model UTIs and phage therapy, showing phage reduces bacterial loads and inflammation during infection.

This study shows that Tamm-Horsfall protein enhances neutrophil NETosis during UTI by modulating respiratory chain, granules, and chromatin remodeling pathways.