Laura Brueckner

The paper integrates 4D Nucleome data to analyze 3D genome structure and function in human cells, revealing chromatin domains, loops, and interactions, and showing how genetic variants affect genome folding.

The paper manipulates transcription to show it can advance replication timing but is not required for the switch to early replication.

The paper investigates how gene activation affects nuclear lamina interactions and shows that transcription can locally rewire these interactions without broadly altering chromosomal regions.

The paper shows that LADs create a repressive chromatin environment that affects promoter activity and transcription elongation, with variability in promoter sensitivity to LAD repression.

This study shows that ACF1-containing chromatin remodeling complexes repress gene expression by maintaining a repressive chromatin state in Drosophila.