Cancer BiologybioRxivPreprint
Activation of the TP53 pathway is a therapeutic vulnerability in NUP98::KDM5A+ pediatric AML
L. Cifarelli, Hasan Issa, Ludovica Proietti…·Dirk Heckl
This study identifies TRIP13 as a developmentally restricted dependency in NUP98::KDM5A+ pediatric AML, showing that its inhibition reactivates TP53 and kills leukemic cells.
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