Ielyaas Cloete

Dynamical analysis of a model of BCL-2-dependent cellular decision making

This study uses mathematical modeling to show that BCL-2 network architecture enables tristability in cell-fate decisions, with stochastic fluctuations driving heterogeneous outcomes.

A Mathematical Exploration of SDH-b Loss in Chromaffin Cells

This study uses a mathematical model to explore how chromaffin cells maintain electron transport chain function despite SDH-b loss, revealing mechanisms that support cell survival.

Targeted inhibition of Bcl-xL following radiation reduces tumourigenesis in preclinical models of H3K27M-altered diffuse midline glioma

This study shows that combining radiation with Bcl-xL inhibition reduces tumor growth in preclinical models of H3K27M-altered diffuse midline glioma.

Pyruvate from bone marrow mesenchymal stem cells supports myeloma redox homeostasis and anabolism

This study shows that pyruvate from bone marrow mesenchymal stem cells supports myeloma cell redox homeostasis and anabolism through MCT-1/2 transporters.

Computational modeling of DLBCL predicts response to BH3-mimetics.

This study uses computational systems biology to predict DLBCL cell response to BH3-mimetics by modeling molecular variability and genetic lesions.