Monitoring lysosomal catabolism: a sensitive probe for assessing targeted lysosomal degradation of extracellular proteins
Ryan W. Holly, Yizhen Hu, Vaishnavi Beena Valsan, Christos M. Kougentakis, Nektaria Petronikolou, Tao Chen, Diana Li, Aimei Chen, Steve Rank, Kyle H. Doran, Eric D. Turtle, Chris Langsdorf, Matthew J. Shurtleff
The paper develops a fluorescent probe to monitor lysosomal catabolism of internalized proteins and applies it to assess therapeutic LYTAC agents.
bioRxiv · Oct 18, 2024 · PreprintCell Biology