Jibin John

This paper decomposes the genetic architecture of schizophrenia and bipolar disorder into shared and disorder-specific components, revealing distinct biological pathways and associations with intermediate traits.

This study identifies plasma proteins linked to brain structure and neurological disorders using multi-omics integration and Mendelian randomization.

This paper identifies genetic loci associated with schizophrenia and bipolar disorder using cognitive pleiotropy, revealing shared and disorder-specific biological mechanisms.

The paper introduces DIMPLE-GWAS, a dimensionality reduction framework for GWAS of brain scans, identifying 25 latent phenotypes with higher heritability and discovering 104 new significant loci.

The paper evaluates how using polygenic risk scores (PRS) or monogenic testing (PGT-M) for breast cancer risk can lead to errors in embryo selection due to interactions between genetic variants.

The paper uses pleiotropy between schizophrenia and cognitive traits to identify genetic loci and their biological pathways, finding distinct associations with neurodevelopmental and synaptic functions.

The paper identifies inherited rare variants in schizophrenia families, showing enrichment in neurodevelopmental pathways and convergence with genes linked to de novo mutations in schizophrenia, autism, and intellectual disability.