Bittianda Kuttapa Thelma

ARL15 promotes inflammatory fibroblast activation and disease severity in rheumatoid arthritis: integrated transcriptomic and collagen-induced arthritis model analyses

This study identifies ARL15 as a pro-inflammatory driver of rheumatoid arthritis by integrating transcriptomic, single-cell, and in vivo analyses, showing its therapeutic potential through inhibition in a mouse model.

Dissecting ARL15 Function in Rheumatoid Arthritis: Insights from Ex Vivo and In Vitro Synovial Fibroblast Models

This study investigates ARL15's role in rheumatoid arthritis using gene knockdown in synovial fibroblasts and cell lines, revealing its impact on inflammation, extracellular matrix, and immune response.

Genetic affinities and sub-structuring in Coorg population of Southern India

This study investigates the genetic structure and demographic history of the Coorg population in Southern India using autosomal and uniparental markers, revealing ancient origins and population substructure.

Deletion induced splicing in RIC3 drives nicotinic acetylcholine receptor regulation with implications for endoplasmic reticulum stress in human astrocytes

The paper investigates how a deletion in RIC3 affects splicing and nAChR regulation in human astrocytes under ER stress, identifying potential therapeutic targets.

Genome Wide Study of Tardive Dyskinesia in Schizophrenia

This study performs the largest GWAS of tardive dyskinesia, identifies novel and suggestive loci, and explores polygenic risk and biological pathways.

Trans-ethnic analysis of the human leukocyte antigen region for ulcerative colitis reveals shared but also ethnicity-specific disease associations

This study identifies shared and ethnicity-specific HLA associations with ulcerative colitis through trans-ethnic analysis of diverse populations.

Cumulative effect of aging and SARS-CoV2 infection on poor prognosis in the elderly: Insights from transcriptomic analysis of lung and blood

The paper analyzes transcriptomic data to show that SARS-CoV-2 infection exacerbates aging-related gene expression changes in elderly patients, leading to poor prognosis.

Oligogenic rare variant contributions in schizophrenia and their convergence with genes harboring de novo mutations in schizophrenia, autism, and intellectual disability: Evidence from multiplex families

The paper identifies inherited rare variants in schizophrenia families, showing enrichment in neurodevelopmental pathways and convergence with genes linked to de novo mutations in schizophrenia, autism, and intellectual disability.