Max Lam

Disorder-specific and shared genetic architecture underlying schizophrenia and bipolar disorder

This paper decomposes the genetic architecture of schizophrenia and bipolar disorder into shared and disorder-specific components, revealing distinct biological pathways and associations with intermediate traits.

Characterizing the impact of plasma protein levels on human brain structure and disorders leveraging integrative multi-omics analysis

This study identifies plasma proteins linked to brain structure and neurological disorders using multi-omics integration and Mendelian randomization.

Cognitive pleiotropy reveals disorder-specific and shared biology for schizophrenia and bipolar disorder

This paper identifies genetic loci associated with schizophrenia and bipolar disorder using cognitive pleiotropy, revealing shared and disorder-specific biological mechanisms.

A Pleiotropic Map of Brain Imaging Genetics Reveals Biologically Distinct Latent Endophenotypes

The paper introduces DIMPLE-GWAS, a dimensionality reduction framework for GWAS of brain scans, identifying 25 latent phenotypes with higher heritability and discovering 104 new significant loci.

High-throughput plasma proteomic platforms: Insights from a multi-ethnic Asian cohort

The paper compares three proteomic platforms in a multi-ethnic Asian cohort, finding limited overlap, platform-specific performance metrics, and ethnicity-related protein differences.

Dissecting Schizophrenia Biology Using Pleiotropy with Cognitive Genomics

The paper uses pleiotropy between schizophrenia and cognitive traits to identify genetic loci and their biological pathways, finding distinct associations with neurodevelopmental and synaptic functions.

Fine-mapping across diverse ancestries drives the discovery of putative causal variants underlying human complex traits and diseases

This paper introduces SuSiEx, a cross-population fine-mapping method that improves resolution and power by integrating data across ancestries, leading to more accurate identification of causal variants in complex traits and diseases.

Metabolome-wide association of carotid intima media thickness identifies FDX1 as a determinant of cholesterol metabolism and cardiovascular risk in Asian populations.

Genetic variants for head size share genes and pathways with cancer

This study identifies 67 genetic loci associated with head size, finding strong overlaps with cancer pathways and genes, suggesting shared genetic mechanisms between head growth and cancer risk.

The impact of rare protein coding genetic variation on adult cognitive function

This study identifies eight genes associated with adult cognitive function through rare coding variants and shows how KDM5B dosage affects cognitive traits in mice and humans.

GWAS of Over 427,000 Individuals Establishes GABAergic and Synaptic Molecular Pathways as Key for Cognitive Executive Functions

This study performs a large-scale GWAS on executive functions, identifying genetic variants linked to synaptic and GABAergic pathways and showing distinct genetic relationships with intelligence and psychiatric disorders.

T-SEM of 11 Major Psychiatric Disorders: Identification of Gene Expression Patterns for Cross-Disorder Risk and Drug Repurposing

This study uses T-SEM to identify gene expression patterns linked to genetic overlap and disorder-specific risk in psychiatric disorders, finding potential drug repurposing targets.

Improving Polygenic Prediction in Ancestrally Diverse Populations

This paper introduces PRS-CSx, a method that improves polygenic prediction across ancestrally diverse populations by integrating GWAS summary statistics and sharing genetic effects.

Mapping genomic loci prioritises genes and implicates synaptic biology in schizophrenia

A genome-wide association study of 69,369 schizophrenia cases and 236,642 controls identifies 270 risk loci, prioritizes 130 genes, and links common and rare risk variants to neuronal synaptic biology.

Genome Wide Study of Tardive Dyskinesia in Schizophrenia

This study performs the largest GWAS of tardive dyskinesia, identifies novel and suggestive loci, and explores polygenic risk and biological pathways.

Identifying Nootropic Drug Targets via Large-Scale Cognitive GWAS and Transcriptomics

This paper identifies potential nootropic drug targets by integrating large-scale cognitive GWAS and transcriptomic data to find credible druggable genes.

Whole exome sequencing in the UK Biobank reveals risk gene SLC2A1 and biological insights for major depressive disorder

The paper analyzes whole exome sequencing data from the UK Biobank to identify rare coding variants associated with major depressive disorder and reveals genetic overlaps with other psychiatric disorders.

Novel ultra-rare exonic variants identified in a founder population implicate cadherins in schizophrenia

The paper identifies ultra-rare exonic variants in an Ashkenazi Jewish founder population, implicating cadherins in schizophrenia through recurrent mutations and altered purifying selection.

Elucidating the Joint Genetic Architecture of Mood Disorder and Schizophrenia

This study identifies 308 genetic loci associated with mood disorder and schizophrenia across East Asian and European populations, revealing shared and distinct genetic mechanisms.

The genetic architecture of the human cerebral cortex

The paper identifies genetic loci associated with human cortical structure and finds genetic correlations with neuropsychiatric disorders.

Comparative genetic architectures of schizophrenia in East Asian and European populations

This study identifies schizophrenia genetic associations in East Asian and European populations, finding similar genetic effects across ancestries but highlighting challenges in polygenic risk prediction across groups.

Screening human embryos for polygenic traits has limited utility

This paper evaluates the potential benefits of using polygenic scores to select embryos for traits like height and cognitive function, finding limited gains with current predictors.

RICOPILI: Rapid Imputation for COnsortias PIpeLIne

RICOPILI is a Perl-based pipeline for efficient GWAS analysis, including quality control, imputation, and meta-analysis, with automated parallelization for rapid data processing.

Pleiotropic Meta-Analysis of Cognition, Education, and Schizophrenia Differentiates Roles of Early Neurodevelopmental and Adult Synaptic Pathways

The paper uses pleiotropic meta-analysis to identify genetic loci associated with cognition, education, and schizophrenia, revealing distinct biological mechanisms for concordant and discordant genetic correlations.

GWAS meta-analysis (N=279,930) identifies new genes and functional links to intelligence

This study identifies 206 new genomic loci and 1,041 genes associated with intelligence using a large GWAS meta-analysis of 279,930 individuals.

Ninety-nine independent genetic loci influencing general cognitive function include genes associated with brain health and structure (N = 280,360)

This study identifies 99 genetic loci associated with general cognitive function using data from 280,360 individuals, finding genes linked to brain structure and neurodegenerative disorders.

Large-Scale cognitive GWAS Meta-analysis Reveals Tissue-Specific Neural Expression and Potential Nootopic Drug Targets

This study performs a large-scale GWAS of cognitive ability, identifies 70 genomic loci, and finds tissue-specific gene expression and potential drug targets.