Stephanie D. Wolf

This study identifies ECM1 as a gatekeeper that transiently suppresses HGF activity during liver regeneration, enabling tissue repair through c-MET-ERK-MYC signaling.

Endogenous immunoglobulin G (IgG) immunostaining quantitatively labels apoptotic and necrotic hepatocytes across acute and chronic murine liver injury models, outperforming serum transaminases and histopathological Ishak scoring.

This paper develops a digital twin model to simulate liver fibrosis patterns, showing that ECM distribution results from cell death zones and biomechanical compression.