Chenjun Huang

This study identifies ECM1 as a gatekeeper that transiently suppresses HGF activity during liver regeneration, enabling tissue repair through c-MET-ERK-MYC signaling.

The paper identifies a YB-1-mA-DNMT regulatory axis that drives cisplatin resistance in iCCA by promoting ABCB1 expression through promoter demethylation.

This study identifies super-enhancers as critical regulators of liver function genes in hepatocytes and liver progenitor cells during health and acute liver failure.

This study shows ECM1 prevents hepatic fibrosis by inhibiting TGF-β1 activation, with implications for developing safe anti-fibrotic therapies.

This study identifies EGF/STAT1 and IFNγ/NRF2 signaling pathways regulating ECM1 expression, showing their role in maintaining liver homeostasis versus promoting chronic liver disease.

This paper introduces OPERA, a method for detecting low-frequency mutations in short and rare cell-free DNA, achieving higher sensitivity than existing methods.