Author

Kathleen W. Kurgan

University of BristolORCID 0000-0002-0621-9535Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Synthetic Biology· 1 Systems Biology· 1

Signature Assays, Organisms & Methods

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Assay:protein structure· 2 Approach:experimental assay· 1 Approach:machine learning (classical)· 1 Research Focus:protein design· 1 Approach:statistical model· 1

Frequent Co-Authors

Derek N. WoolfsoniD· 2 shared Aimee L. BoyleiD· 1 shared Amanda M. Acevedo‐JakeiD· 1 shared Andrew J. Orr‐EwingiD· 1 shared Andrew John WilsoniD· 1 shared Andrey V. RomanyukiD· 1 shared Bram MylemansiD· 1 shared Christine Anne OrengoiD· 1 shared

Activity by Year

2024-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 31 mutual co-author links

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2 shared papersSynthetic Biology

Derek N. WoolfsonORCID

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2 papers

Recent·Most cited

Expanding all-α-helical protein space through rational computational design

Katherine I. Albanese, Joel J. Chubb, Luis I. Gutierrez-Rus, Xiyue Leng, Kathleen W. Kurgan, Bram Mylemans, Katarzyna Ożga, Rokas Petrenas, Andrey V. Romanyuk, Amanda M. Acevedo‐Jake, Joel Roca‐Martínez, Stephen Cross, J. L. Ross Anderson, Jonathan Clayden, Graham J. Leggett, , Derek N. Woolfson

The paper designs de novo all-α-helical proteins using computational methods and validates their stability and structure.

bioRxiv · Jul 3, 2026 · PreprintSynthetic Biology

Exchange, promiscuity, and orthogonality in de novo designed coiled-coil peptide assemblies

Kathleen W. Kurgan, Freddie J. O. Martin, William Dawson, Tom Brunnock, Andrew J. Orr‐Ewing, Derek N. Woolfson

The paper develops a fluorescence-based assay to study peptide exchange in de novo coiled-coil assemblies and identifies strategies to improve orthogonality between oligomeric states.

bioRxiv · Sep 1, 2024 · PreprintSystems Biology