Ana Cláudia Raposo

This study shows XCI erosion in female hiPSCs is common, heterogeneous, and persists during differentiation, affecting X-linked gene expression without altering DNA methylation levels.

The paper shows that donor cell sex and reprogramming conditions affect imprinting defects in mouse iPSCs, with distinct methylation patterns observed under different culture conditions.

The paper tracks H3K27me3 and H4K20me1 dynamics during XCI and finds they accumulate concurrently but have distinct genomic distributions, with H4K20me1 possibly contributing to chromatin compaction.

This study investigates the role of Polycomb recruitment in Xist-mediated X chromosome silencing in mouse ES cells, finding that silencing can occur independently of Polycomb complexes.