Paul Robert Shearing

Anatomical and functional organization of cardiac fibers in the porcine cervical vagus nerve allows spatially selective efferent neuromodulation

This paper demonstrates spatially-selective vagus nerve stimulation (sVNS) can target cardiac efferent fibers to decrease heart rate without stimulating afferent-related reflexes, improving precision and efficacy of neuromodulation for cardiac disease.

Human vagus nerve fascicular anatomy: a microCT segmentation and histological study

This study uses microCT and histology to analyze the fascicular organization of human vagus nerves, revealing differences between left and right nerves and potential for targeted neuromodulation.

Organotopic organization of the cervical vagus nerve

The paper identifies localized fascicles in the porcine cervical vagus nerve that correspond to specific organ functions, supporting the concept of organotopy and enabling targeted neuromodulation.

MicroCT optimisation for imaging fascicular anatomy in peripheral nerves

The paper optimizes microCT protocols to segment and track fascicles in rat sciatic and pig vagus nerves, aiming to improve VNS targeting and reduce off-target effects.