Author

David Micklem

BerGenBio (Norway)ORCID 0000-0003-2756-2591Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Organism:human· 1 Research Focus:protein folding & dynamics· 1 Assay:protein structure· 1 Research Focus:protein structure prediction· 1 Assay:structural biology· 1

Frequent Co-Authors

Eleni ChristakouiD· 2 shared Petri KursulaiD· 2 shared Andrea J. LópeziD· 1 shared Gopinath MuruganandamiD· 1 shared James B. LorensiD· 1 shared

Activity by Year

2025-2025 · peak 2/yr

Co-Author Collaboration Network

5 top collaborators · 10 mutual co-author links

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2 shared papersBiochemistry

Eleni ChristakouORCID

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2 papers

Recent·Most cited

BiochemistryACS OmegaPeer-reviewedDec 22, 2025

Structural analysis of tilvestamab in complex with AXL

Eleni Christakou, Andrea J. López, Gopinath Muruganandam…·Petri Kursula

The paper presents a structural analysis of the AXL-tilvestamab complex using cryo-EM and SAXS, providing a low-resolution 3D model and insights for optimizing binding affinity.

DOI 10.1021/acsomega.5c10003

structural biologyexperimental assay

𝕏 PostBluesky

BiochemistryBioscience ReportsPeer-reviewedSep 26, 2025

Paratope mapping of tilvestamab, an anti-AXL function blocking antibody, using high-throughput bacterial expression of secreted scFv-ompY fusion proteins

Eleni Christakou, Petri Kursula, David Micklem

This study maps the paratope residues of tilvestamab, an anti-AXL antibody, identifying twelve critical residues and Glu2 on AXL essential for binding.

DOI 10.1042/bsr20253747

humanprotein structure

𝕏 PostBluesky