Author

James B. Lorens

University of BergenORCID 0000-0002-6782-3349Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Research Focus:cell type annotation· 2 Research Focus:differential expression· 2 Approach:experimental assay· 2 Organism:human· 2 Assay:bulk RNA-seq· 1 Research Focus:cell-cell communication· 1 Approach:machine learning (classical)· 1 Research Focus:protein structure prediction· 1

Frequent Co-Authors

Sturla Magnus GrøndaliD· 2 shared Andrea J. LópeziD· 1 shared Chang CheniD· 1 shared David MicklemiD· 1 shared Edward J Hester· 1 shared Eleni ChristakouiD· 1 shared Gopinath MuruganandamiD· 1 shared Jennifer C. LopeziD· 1 shared

Activity by Year

2024-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 21 mutual co-author links

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Focal author (center)Selected co-authorORCID co-authorUnlinked name

Curved chords = mutual co-authorship

2 shared papersCancer Biology

Sturla Magnus GrøndalORCID

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

MechanoAge, a machine learning platform to identify individuals susceptible to breast cancer based on mechanical properties of single cells

Stefan Hinz, Sturla Magnus Grøndal, Masaru Miyano, Jennifer C. Lopez, Kristen L. Cotner, Taylor Thomsen, Chang Chen, Edward J Hester, Lisa D. Yee, Victoria L. Seewaldt, James B. Lorens, Lydia Lee Sohn, Mark A. LaBarge

This paper develops MechanoAge, a machine learning tool that identifies breast cancer risk based on single-cell mechanical properties and introduces mechano-RISQ to quantify risk-related mechanical deviations.

EBioMedicine · Apr 24, 2026Peer-reviewedCancer Biology

Structural analysis of tilvestamab in complex with AXL

Eleni Christakou, Andrea J. López, Gopinath Muruganandam, David Micklem, James B. Lorens, Petri Kursula

The paper presents a structural analysis of the AXL-tilvestamab complex using cryo-EM and SAXS, providing a low-resolution 3D model and insights for optimizing binding affinity.

ACS Omega · Dec 22, 2025Peer-reviewedBiochemistry

Interactions between neutrophils and macrophages harboring gram-negative bacteria promote obesity-associated breast cancer

Sina T. Takle, Sturla Magnus Grøndal, Martin E. Lien, Priscilia Lianto, Wei Deng, Reidun Lillestøl, Per Eystein Lønning, James B. Lorens, Stian Knappskog, Nils Halberg

The paper identifies a cellular network involving neutrophils and M2 macrophages in obese breast cancer patients that promotes tumor growth through bacterial LPS and S100A8.

bioRxiv · Aug 8, 2024 · PreprintCancer Biology