Péter Tompa

This study identifies multivalent ubiquitin recognition as a regulator of Tau self-assembly stages, showing ubiquitin's role in modulating condensate formation and aggregation.

This study shows disease-linked mutations in hnRNPA2B1 accelerate condensate maturation and promote amyloid aggregation by altering phase separation and fibril formation.

This study identifies the RNA-binding region of the androgen receptor and shows how lncRNA binding modulates interdomain communication and phase separation, contributing to ligand-independent AR signaling in prostate cancer.

This study reports the successful expression and purification of full-length hnRNPA2B1, enabling its use in studying liquid-liquid phase separation and aggregation.

The paper provides benchmark sets to evaluate AlphaFold applications without data leakage, showing the need for careful parameter optimization in disordered prediction.

This study shows that C9orf72-derived arginine-rich dipeptide repeats enhance G3BP1 phase separation, contributing to ALS and FTD pathology.

This study shows that polystyrene sulfonate (PSS) reduces toxicity of ALS-linked dipeptide repeat proteins in cellular and iPSC-derived motor neuron models.

The paper evaluates 43 methods for predicting intrinsically disordered regions and binding regions in proteins, finding that deep learning methods outperform older physicochemical approaches but binding prediction remains challenging.

The paper examines the concentration sensitivity of proteins involved in liquid-liquid phase separation and argues that in vitro concentrations are reasonable given cellular dosage sensitivity.

The paper introduces a method to study liquid-liquid phase separation under near-native conditions by using extreme pH to control protein solubility and induce phase separation.

The paper introduces superimposition-free metrics to compare conformational ensembles of intrinsically disordered proteins by analyzing residue-residue distance distributions.