Tamás Lázár

This study identifies multivalent ubiquitin recognition as a regulator of Tau self-assembly stages, showing ubiquitin's role in modulating condensate formation and aggregation.

The paper demonstrates that negative design, which locally destabilizes β-strands, improves folding efficiency of synthetic transmembrane β-barrels in a cell-free system.

This study reports the successful expression and purification of full-length hnRNPA2B1, enabling its use in studying liquid-liquid phase separation and aggregation.

The paper defines the binding preference of tandem SH3 domains in p47phox-related proteins and identifies potential new instances through integrative analysis and structure prediction.

This study shows that C9orf72-derived arginine-rich dipeptide repeats enhance G3BP1 phase separation, contributing to ALS and FTD pathology.

The paper systematically evaluates HINT1 variants causing NMAN using structural and functional analyses to classify their pathogenicity and guide personalized therapies.

The paper evaluates 43 methods for predicting intrinsically disordered regions and binding regions in proteins, finding that deep learning methods outperform older physicochemical approaches but binding prediction remains challenging.

The paper examines the concentration sensitivity of proteins involved in liquid-liquid phase separation and argues that in vitro concentrations are reasonable given cellular dosage sensitivity.

The paper introduces superimposition-free metrics to compare conformational ensembles of intrinsically disordered proteins by analyzing residue-residue distance distributions.