Edra London

This study investigates how opioid receptors modulate glutamatergic and cholinergic neurotransmission in the medial habenula/interpeduncular nucleus circuit, revealing complex developmental regulation and interactions with potassium channels.

The paper shows that opioids suppress inhibition in hippocampal PV-INs but not neocortex across species and development, highlighting conserved and divergent roles in neural circuits.

The paper identifies de novo PRKAR1B variants in six individuals with neurodevelopmental disorder, autism, apraxia, and reduced pain sensitivity.