Ramesh Chittajallu

Reducing methylation of histone 3.3 lysine 4 in the medial ganglionic eminence and hypothalamus recapitulates neurodevelopmental disorder phenotypes

This study shows that reducing H3K4 methylation in specific brain regions causes neurodevelopmental disorder-like phenotypes, including seizures, growth issues, and behavioral deficits.

Complex opioid driven modulation of glutamatergic and cholinergic neurotransmission in a GABAergic brain nucleus associated with emotion, reward and addiction.

This study investigates how opioid receptors modulate glutamatergic and cholinergic neurotransmission in the medial habenula/interpeduncular nucleus circuit, revealing complex developmental regulation and interactions with potassium channels.

Discrete interneuron subsets participate in GluN1/GluN3A excitatory glycine receptor (eGlyR)-mediated regulation of hippocampal network activity throughout development and evolution.

The paper shows that eGlyRs in hippocampal interneurons regulate network activity through developmental and evolutionary conserved mechanisms.

An enhancer-AAV toolbox to target and manipulate distinct interneuron subtypes

The paper identifies enhancer-AAV tools for specific neuronal subtypes and validates them across species.

Divergent opioid-mediated suppression of inhibition between hippocampus and neocortex across species and development

The paper shows that opioids suppress inhibition in hippocampal PV-INs but not neocortex across species and development, highlighting conserved and divergent roles in neural circuits.

NMDAR-mediated transcriptional control of gene expression during the development of medial ganglionic eminence-derived interneurons

This study identifies Grin1 as a key regulator of subtype-specific gene expression in MGE-derived interneurons, linking NMDAR signaling to neurodevelopmental disorders like schizophrenia.

Viral manipulation of functionally distinct neurons from mice to humans

The paper identifies enhancers for targeting specific neuronal subtypes across species and demonstrates their utility in circuit manipulation.

Activity-dependent tuning of intrinsic excitability in mouse and human neurogliaform cells

The paper shows that neurogliaform cells in mouse and human exhibit similar activity-dependent changes in intrinsic excitability, suggesting conserved circuit mechanisms across species.