Ralph Stadhouders

This study identifies KIT+ ILC2s as an epigenomically plastic state linked to immune disease susceptibility and shows that STAT5 activation by cytokines induces this phenotype.

The paper studies alternative splicing dynamics during mouse B cell reprogramming into iPS cells and identifies three RNA-binding proteins involved in splicing regulation.

The paper identifies spatially clustered genes with multiple enhancers as frequent targets of HIV-1 integration in T cells.

The paper introduces TADdyn, a tool that simulates chromatin structural rearrangements during cell reprogramming using time-course 3C data and molecular dynamics, revealing a hit-and-stick mechanism for transcriptional stabilization.

The paper investigates the effects of the Klf1 Nan variant on erythroid maturation, finding that it causes nuclear condensation defects and deregulates Xpo7 expression.

OneD improves Hi-C reproducibility for samples with abnormal karyotypes by addressing copy number variations, outperforming existing methods while maintaining performance on normal karyotypes.

The paper shows transcription factors drive genome topology changes before gene expression during cell reprogramming.

The paper compares two Hi-C samples, showing how adherence to FAIR principles leads to successful sequencing projects.