Author

Gretchen L. Seim

GenentechORCID 0000-0002-7785-1378Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Organism:human· 2 Assay:bulk RNA-seq· 1 Research Focus:cell type annotation· 1 Research Focus:cell-cell communication· 1 Research Focus:differential expression· 1 Research Focus:host-pathogen & immune response· 1 Assay:metabolomics· 1

Frequent Co-Authors

Bridget E. ShieldsiD· 1 shared Carlos Mellado FritziD· 1 shared Carrie M. RosenbergeriD· 1 shared Cynthia CheniD· 1 shared Daniel Amador‐NogueziD· 1 shared Donghong YaniD· 1 shared Felicia Deng· 1 shared Hannah Little-Hooy· 1 shared

Activity by Year

2025-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 20 mutual co-author links

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1 shared paperBiochemistry

Bridget E. ShieldsORCID

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2 papers

Recent·Most cited

Discovery of metabolites produced by reactions between central carbon metabolites and cysteine that mark inflammatory macrophages

Nicholas L. Arp, Felicia Deng, Jorgo Lika, Gretchen L. Seim, Paulo Falco Cobra, Carlos Mellado Fritz, Steven V John, Swetha Rathinaraj, Bridget E. Shields, Daniel Amador‐Noguez, Katherine A. Henzler‐Wildman, Jing Fan

The paper identifies sulfur-containing metabolites specific to inflammatory macrophages, showing they are produced from cysteine and central metabolism intermediates and are elevated in human inflammatory lesions.

bioRxiv · Mar 20, 2026 · PreprintBiochemistry

G-CSF and IL-6 drive myeloid dysregulation during severe viral infection

Kimberly K. Kajihara, Donghong Yan, Gretchen L. Seim, Hannah Little-Hooy, Jing‐Qiong Kang, Cynthia Chen, Marco Claudio De Simone, Tim Delemarre, Spyros Darmanis, Haridha Shivram, Rebecca N. Bauer, Carrie M. Rosenberger, Sharookh B. Kapadia, Min Jian Xu, Miguel Reyes

This study identifies G-CSF and IL-6 as drivers of myeloid dysregulation during severe viral infection, showing their role in emergency myelopoiesis and tissue injury.

Communications Biology · Jul 23, 2025Peer-reviewedImmunology