De novo synthesis of a conjugative system from human gut metagenomic data for targeted delivery of Cas9 antimicrobials
Thomas A. Hamilton, Benjamin R. Joris, Arina Shrestha…·David R. Edgell
Author
Western UniversityORCID 0000-0003-2786-6317Unclaimed ORCID profile · follow to get notified of new preprints
4 papers
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Thomas A. Hamilton, Benjamin R. Joris, Arina Shrestha…·David R. Edgell
Henry Say, Benjamin R. Joris, Daniel J. Giguere, Gregory Brian Gloor
The paper improves functional annotations of metagenomic bacteriophage by combining protein structure prediction and homology search in a naphthenic acid-degrading microbial community.
Benjamin R. Joris, Tyler S. Browne, Thomas A. Hamilton…·Gregory Brian Gloor
The paper identifies type IV conjugation systems in metagenomic data and shows they differ between age and geographic cohorts, suggesting their use as biomarkers and highlighting limitations of current binning methods.
Daniel J. Giguere, Alexander T. Bahcheli, Benjamin R. Joris…·Gregory Brian Gloor
The paper presents a strategy to complete and validate metagenome-assembled genomes using a combination of short and ultra-long reads, resulting in multiple complete genomes from a bacterial community.