Thomas E. Spencer

This study shows that luminal epithelium, not glandular cells, drives endometrial regeneration during menstruation and pregnancy in mice, revealing a unifying mechanism for tissue repair.

This study shows that transplanting endometrial organoids restores fertility and reveals luminal-to-glandular epithelial plasticity in the adult endometrium.

The paper identifies a transient epithelial plasticity state that regulates uterine gland specification through ESR1, retinoic acid signaling, and FOXA2.

The study shows that ejaculated sperm, exposed to accessory gland secretions, induce a different endometrial transcriptomic response than epididymal sperm in cattle.

The paper identifies extensive gene regulatory rewiring between in vitro-produced conceptuses and endometrium during implantation, contributing to pregnancy loss in cattle.

The paper integrates ESR1 cistrome and transcriptome data from endometrial biopsies and organoids to identify estrogen-regulated genes and their functional roles in endometrial health.

This paper develops a mouse strain with decidua-specific Cre recombinase expression to study decidualization and infertility.

The paper identifies PGR-regulated genes and pathways in endometrium during the window of implantation using RNA-seq and PGR-ChIP-seq.