Tianyuan Wang

Fate (or state) of CA2 neurons in a mineralocorticoid receptor knockout.

The paper investigates the effects of mineralocorticoid receptor knockout on CA2 neurons, finding they adopt a CA1-like molecular and morphological phenotype.

WUREN: Whole-modal fUsion Representation for protein interaction interfacE predictioN

WUREN is a multimodal model that fuses sequence, graph, and structural features to predict protein interaction interfaces and antigen epitopes, achieving state-of-the-art performance.

The estrogen receptor α cistrome in human endometrium and epithelial organoids

The paper integrates ESR1 cistrome and transcriptome data from endometrial biopsies and organoids to identify estrogen-regulated genes and their functional roles in endometrial health.

WNK1 regulates uterine homeostasis and its ability to support pregnancy

This study identifies WNK1's role in uterine homeostasis and pregnancy by showing its regulation of AKT signaling through PP2A in endometrial cells.

Mutations on a novel brain-specific isoform of PGC1α leads to extensive upregulation of neurotransmitter-related genes and sexually dimorphic motor deficits in mice

This study shows that a brain-specific PGC1α isoform mutation causes motor deficits and gene upregulation in female mice, suggesting a role in female-specific transcriptional programs.

Maternal exposure to a mitochondrial toxicant results in life-long alterations in DNA methylation and gene expression in the offspring

This study shows that maternal exposure to rotenone alters DNA methylation and gene expression in offspring, with long-term effects on health and disease.

Dynamic Transcriptome, Accessible Genome and PGR Cistrome Profiles in the Human Myometrium

Term-pregnant versus nonpregnant human myometrium shows 2890 differentially expressed genes, more open chromatin regions (85777 vs 45501), and progesterone receptor binding shifted from promoters toward distal sites.

Human Endometrial Transcriptome and Progesterone Receptor Cistrome Reveal Important Pathways and Epithelial Regulators

The paper identifies PGR-regulated genes and pathways in endometrium during the window of implantation using RNA-seq and PGR-ChIP-seq.

Mitochondrial acetyl-CoA reversibly regulates locus-specific histone acetylation and gene expression

This study shows that mitochondrial acetyl-CoA reversibly modulates histone acetylation and gene expression in models of mtDNA depletion.

Multiethnic Meta-analysis Identifies New Loci for Pulmonary Function

This study identifies over 50 new genetic loci associated with pulmonary function through a multiethnic meta-analysis of 90,715 individuals.