San‐Pin Wu

The estrogen receptor α cistrome in human endometrium and epithelial organoids

The paper integrates ESR1 cistrome and transcriptome data from endometrial biopsies and organoids to identify estrogen-regulated genes and their functional roles in endometrial health.

Inserting Cre Recombinase into the Prolactin 8a2 gene for Decidua-Specific recombination in Mice

This paper develops a mouse strain with decidua-specific Cre recombinase expression to study decidualization and infertility.

WNK1 regulates uterine homeostasis and its ability to support pregnancy

This study identifies WNK1's role in uterine homeostasis and pregnancy by showing its regulation of AKT signaling through PP2A in endometrial cells.

Increased FOXL2 Expression Alters Uterine Structures and Functions

This study shows that increased FOXL2 expression in the female reproductive tract causes uterine structural and functional abnormalities, contributing to infertility and endometriosis progression.

Whole exome sequencing identifies novel DYT1 dystonia-associated genome variants as potential disease modifiers

The paper identifies novel genome variants associated with DYT1 dystonia through whole exome sequencing and suggests they may modify disease penetrance.

Dynamic Transcriptome, Accessible Genome and PGR Cistrome Profiles in the Human Myometrium

Term-pregnant versus nonpregnant human myometrium shows 2890 differentially expressed genes, more open chromatin regions (85777 vs 45501), and progesterone receptor binding shifted from promoters toward distal sites.

Human Endometrial Transcriptome and Progesterone Receptor Cistrome Reveal Important Pathways and Epithelial Regulators

The paper identifies PGR-regulated genes and pathways in endometrium during the window of implantation using RNA-seq and PGR-ChIP-seq.

Association of SYNE2 variants in accelerating the progress of DYT1 early-onset isolated dystonia

The paper identifies SYNE2 variants associated with earlier onset of DYT1 dystonia by affecting TOR1A-SYNE2 protein interactions in a family with TOR1A mutations.