Chen Xie

Quantification and potential functional relevanceof binding cooperativity of adjacent transcriptionfactors on DNA

This paper quantifies binding cooperativity between adjacent transcription factors on DNA and identifies its functional roles in gene regulation.

Patterns of extreme outlier RNA expression in population data reveal sporadic over-activation of genes with co-regulated modules in subsets of individuals

The paper identifies sporadic over-activation of co-regulated genes with extreme outlier RNA expression in multiple species and tissues, showing these patterns are not inherited but may reflect gene regulatory network dynamics.

Fast evolutionary turnover and overlapping variances of sex-biased gene expression patterns defy a simple binary sex-classification of somatic tissues

The paper examines sex-biased gene expression patterns in somatic tissues of mice and humans, finding rapid evolutionary turnover and overlapping variances that challenge a binary sex classification.

Modeling Western Pacific Amyotrophic Lateral Sclerosis and Parkinsonism dementia Complex with Microglia Containing Cerebral Organoids Derived from Induced Pluripotent Stem Cells

This paper uses patient-derived iPSC to generate cerebral organoids modeling ALS-PDC, showing BMAA exposure causes microglial M1 polarization and metabolic dysregulation.

The mutational load in natural populations is significantly affected by high primary rates of retroposition

The study shows that retroposition rates in natural mouse populations are much higher than previously thought, with most events being deleterious and affecting gene expression.

Studying the dawn of de novo gene emergence in mice reveals fast integration of new genes into functional networks

The paper studies three newly emerged genes in mice, showing they quickly integrate into functional networks without extensive adaptive changes.