Molecular BiologybioRxivPreprint
Validation and Long-Term Follow Up of CD33 Off-Targets Predicted In Vitro and In Silico Using Error-Corrected Sequencing in Rhesus Macaques
Aisha A. Aljanahi, Cícera Regina Lazzarotto, Shirley Chen…·Cynthia E. Dunbar
The paper validates off-target effects of CRISPR/Cas9 in rhesus macaques using error-corrected sequencing, showing that in vitro and in silico methods have limited predictive accuracy.
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