Author

Byung‐Chul Lee

National Institutes of HealthORCID 0009-0005-6638-6684Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Organism:rat· 2 Approach:Bayesian inference· 1 Research Focus:benchmarking· 1 Assay:bulk RNA-seq· 1 Research Focus:cell type annotation· 1 Research Focus:differential expression· 1 Research Focus:drug response / drug discovery· 1

Frequent Co-Authors

Cynthia E. DunbariD· 2 shared So Gun HongiD· 2 shared Tae–Hoon ShiniD· 2 shared Yifan ZhouiD· 2 shared Aisha A. AljanahiiD· 1 shared Anthony CookiD· 1 shared Barbara J. FlynniD· 1 shared Beom Hee LeeiD· 1 shared

Activity by Year

2020-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 25 mutual co-author links

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2 shared papersGenetics

Cynthia E. DunbarORCID

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3 papers

Recent·Most cited

GeneticsFrontiers in Veterinary SciencePeer-reviewedJul 6, 2023

Investigation of the Impact of Clonal Hematopoiesis on Severity and Pathophysiology of COVID-19 in Rhesus Macaques

Tae–Hoon Shin, Yifan Zhou, Byung‐Chul Lee…·Cynthia E. Dunbar

This study investigates how clonal hematopoiesis affects COVID-19 severity and pathophysiology in rhesus macaques, finding prolonged inflammation and higher viral persistence in CH animals.

DOI 10.3389/fvets.2023.1182197

ratspatial transcriptomics

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GeneticsbioRxivPreprintJul 22, 2020

A novel PS4 criterion approach based on symptoms of rare diseases and in-house frequency data in a Bayesian framework.

You Kyung Cho, Dhong‐gun Won, Changwon Keum…·Byung‐Chul Lee

This paper introduces a Bayesian framework method called BayesianOR to improve the interpretation of genetic variants for PS4 criteria in rare diseases using in-house frequency data.

2 citations

Bayesian inferencevariant effect prediction

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Molecular BiologybioRxivPreprintJul 5, 2020

Validation and Long-Term Follow Up of CD33 Off-Targets Predicted In Vitro and In Silico Using Error-Corrected Sequencing in Rhesus Macaques

Aisha A. Aljanahi, Cícera Regina Lazzarotto, Shirley Chen…·Cynthia E. Dunbar

The paper validates off-target effects of CRISPR/Cas9 in rhesus macaques using error-corrected sequencing, showing that in vitro and in silico methods have limited predictive accuracy.

1 citation

ratwhole-genome sequencing

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