Aberrant Clonal Hematopoiesis Following Lentiviral Transduction of HSPC in a Rhesus Macaque
Diego A. Espinoza, Xing Fan, Di Yang, Stefan Cordes, Lauren L. Truitt, Katherine R. Calvo, Idalia M. Yabe, Selami Demirci, Kristin J. Hope, So Gun Hong, Allen E. Krouse, Mark E. Metzger, Aylin C. Bonifacino, Rong Lu, Naoya Uchida, , Cynthia E. Dunbar
This paper reports a case of clonal hematopoiesis in a rhesus macaque following lentiviral transduction of HSPC with a strong retroviral promoter, leading to gene overexpression and aberrant splicing.
Molecular Therapy · Apr 9, 2019Peer-reviewedMolecular Biology