Federica Mangione

This study shows that Drosophila histoblasts adjust their proliferation and growth dynamics to compensate for changes in starting tissue size during abdominal development.

The paper shows that tissue growth in Drosophila abdomen stops due to rapid cell cycle arrest, not gradual slowing, and that ECM remodeling is required for expansion.

The paper identifies the Dachsous/Fat/Four-jointed pathway as mediating long-range axial cell orientation during epithelial organization in Drosophila.