Anna P. Ainslie

Growth compensation upon changes in tissue size in the Drosophila abdomen

This study shows that Drosophila histoblasts adjust their proliferation and growth dynamics to compensate for changes in starting tissue size during abdominal development.

Radiotherapy induces persistent innate immune reprogramming of microglia into a primed state

This study shows that radiotherapy primes microglia in rats to have a heightened immune response to future inflammation, and this effect is observed in human brain tissue.

Glioblastoma is associated with extensive accelerated brain ageing

This study shows that brain regions in glioblastoma patients exhibit signs of accelerated ageing similar to Alzheimer's disease, suggesting shared mechanisms of mitochondrial and neuronal dysfunction.

ECM remodeling and spatial cell cycle coordination determine tissue growth kinetics

The paper shows that tissue growth in Drosophila abdomen stops due to rapid cell cycle arrest, not gradual slowing, and that ECM remodeling is required for expansion.